ea0056gp160 | Obesity | ECE2018
Aldiss Peter
, Lewis Jo
, Ebling Fran
, Budge Helen
, Symonds Michael
Background: Therapeutic activation of thermogenic brown adipose tissue (BAT) is a potential strategy to prevent obesity and metabolic disease in humans. However, it is now recognised that rodent studies examining BAT physiology are carried out at sub-thermoneutral temperatures (e.g. ~20°C), and are not translationally relevant to humans as BAT is hyperactive. Therefore, the aim of this study was to determine the effect of common regulators of BAT metabolism wh...